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Zebrafish as a Model for Induction of Transgenerational Inheritance of Disease Due to Environmental Contaminants

Zebrafish as a Model for Induction of Transgenerational Inheritance of Disease Due to Environmental Contaminants

Date 
Thursday, May 25, 2017 - 12:00pm to 1:00pm
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Location 
43-105 CHS
650 Charles E. Young DR S
Los Angeles , CA
California US
Featuring 
Tracie Baker, DVM PhD
Event Contact 

Rebecca Greenberg,  rgreenberg@ph.ucla.edu, 310.206.1619

Dr. Tracie Baker
Tracie Baker, DVM PhD

We have shown that zebrafish (Danio rerio) are an ideal model for evaluating transgenerational effects of certain toxicants and their role in the fetal basis of adult disease. We utilized the zebrafish model to identify transgenerational effects of a known endocrine disrupting chemical (EDC), dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD), on skeletal development, sex determination and male-mediated decreases in reproductive capacity. Exposure to TCDD early in development produces reproductive abnormalities in adulthood and decreased reproductive capacity that persists for multiple, unexposed generations. Since transgenerational inheritance of the effects of TCDD toxicity appears to be mediated through the male germline, histological and gene expression analyses in testicular tissue were evaluated. We identified significant differences in the transcriptome and spermatogenic cell types and between exposed and control groups.