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Impact of Prenatal Pollutant Exposures on Mitochondrial Function, mtDNA methylation, and Metabolic Health in Newborns

Impact of Prenatal Pollutant Exposures on Mitochondrial Function, mtDNA methylation, and Metabolic Health in Newborns

Date 
Thursday, May 18, 2017 - 12:00pm to 1:00pm
Location 
43-105 CHS
650 Charles E. Young DR S
Los Angeles , CA
California US
Featuring 
Carrie Breton, ScD
Event Contact 

Rebecca Greenberg,  rgreenberg@ph.ucla.edu, 310.206.1619

Dr. Carrie Breton
Carrie Breton, ScD

Mitochondria are the cellular organelles that serve as central regulators of metabolism and oxidative stress. Dysfunctional mitochondria have been implicated in a variety of diseases and are important in fetal development. Mitochondria also contain the machinery required to epigenetically modify mtDNA and affect its transcription, suggesting that these modifications may have the ability to affect disease risk. We present evidence that prenatal air pollution exposures, either alone or in combination with mtDNA SNPs, may alter mtDNA methylation and influence child growth using data from 181 newborns in the Maternal and Child Health Study. Specifically, we evaluated traffic related air pollution and ambient air pollution exposures that were estimated based on participants’ residential addresses reported at study entry using California Line-Source Dispersion Model (CALINE4) or routine air monitoring data collected daily in California and available from U.S. Environmental Protection Agency’s Air Quality System, respectively, in relation to birth weight and 6 month infant growth.