In 1976, Dr. Joel Breman, Senior Scientist Emeritus at the Fogarty International Center (U.S. National Institutes of Health) investigated the first outbreak of Ebola hemorrhagic fever during his time in the Democratic Republic of the Congo. In this Grand Rounds, Breman discussed his historic research, as well as his ongoing work to strengthen policy development and research training programs in low-income countries where vaccine-preventable diseases hit hardest.