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Oliver Hankinson

Professor, Director of Molecular Toxicology IDP

Departments

DepartmentsType of Faculty
Environmental Health SciencesJoint Appointment
Contact Information
Phone: 
310.825.2936
Fax: 
310.794.9272

UCLA Path & Lab Med
13-244 Factor Building
Mail Code: 173216
Los Angeles, CA 90095-1732

Dr. Hankinson is a Professor of Pathology and Laboratory Medicine, and Director of the Doctoral Program in Molecular Toxicology. He received his Ph.D. in genetics from Cambridge University, England, in 1972. He did postdoctoral research in mammalian cell genetics at Harvard University, the University of Colorado, and the University of California, Berkeley, before joining the UCLA faculty in 1979. He was Director of the Carcinogenesis program of the UCLA Jonsson Comprehensive Cancer Center from 1994 to 2003, and Vice-Chair for Research of the Department of Pathology from 1997 to 2003. In 2000 he was founding director of the Molecular Toxicology Ph.D. program.

Selected Publications: 

Bui, P.H. Hsu, E.L. Hankinson, O.   Fatty Acid Hydroperoxides Support CYP2S1-Mediated Bioactivation of Benzo[a]pyrene7,8-dihydrodiol, Mol Pharmacol. , 2009; [Epub ahead of print].

Bui, P.H. Hankinson, O.   Functional Characterization of Human Cytochrom P450 2S1 Using a Synthetic Gene-Expressed Protein in E.Coli, Mol. Pharmacol. , 2009; [Epub ahead of print] . 

Hsu, E. L. Chen, N. Westbrook, A. Wang, F. Zhang, R. Taylor, R. T. Hankinson, O.   Modulation of CXCR4, CXCL12, and Tumor Cell Invasion Potential In Vitro by Phytochemicals J Oncol, 2009; 2009(number): 491985. 

Hankinson, O.   Repression of aryl hydrocarbon receptor transcriptional activity by epidermal growth factor Mol Interv, 2009; 9(3): 116-8. 

Beedanagari, S. R. Bebenek, I. Bui, P. Hankinson, O.   Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes Toxicol Sci, 2009; 110(1): 61-7. 

Taylor, R. T. Wang, F. Hsu, E. L. Hankinson, O.   Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells Toxicol Sci, 2009; 107(1): 1-8. 

Shi, S. Yoon, D. Hodge-Bell, K. Bebenek, I. Whitekus, M. Zhang, R. Cochran, A. Huerta Yepez, S. Yim, S.-H. Gonzalez, F.J. Jaiswal, A. Hankinson, O.   The Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt) is required for tumor initiation by benzo(a)pyrene, Carcinogenesis. , 2009; [Epub ahead of print] . 

Buchler, P. Reber, H. A. Tomlinson, J. S. Hankinson, O. Kallifatidis, G. Friess, H. Herr, I. Hines, O. J.   Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer Neoplasia, 2009; 11(2): 196-206. 

Bui, P. H. Quesada, A. Handforth, A. Hankinson, O.   The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil Drug Metab Dispos, 2008; 36(7): 1291-9. 

Hankinson, O.   Why does ARNT2 behave differently from ARNT? Toxicol Sci, 2008; 103(1): 1-3. 

Hsu, E. L. Yoon, D. Choi, H. H. Wang, F. Taylor, R. T. Chen, N. Zhang, R. Hankinson, O.   A proposed mechanism for the protective effect of dioxin against breast cancer Toxicol Sci, 2007; 98(2): 436-44. 

Wang, F. Shi, S. Zhang, R. Hankinson, O.   Comparative microarray analysis of gene expression in mouse Hepa-1c1c7 and B mutant cell lines - the effect of the aromatic hydrocarbon receptor on the phenotype of the cells in the absence of exogenous ligands, Gene Regulation and Systems Biology , 2007; 1: 49-56. 

Rivera, S. P. Saarikoski, S. T. Sun, W. Hankinson, O.   Identification of novel dioxin-responsive genes by representational difference analysis Xenobiotica, 2007; 37(3): 271-9. 

Wang, F. Shi, S. Zhang, R. Hankinson, O.   Identifying target genes of the aryl hydrocarbon receptor nuclear translocator (Arnt) using DNA microarray analysis Biol Chem, 2006; 387(9): 1215-8. 

ARNT Atlas Genet Cytogenet Oncol Haematol, 2004; 

Rivera, S. P. Saarikoski, S. T. Hankinson, O.   Identification of a novel dioxin-inducible cytochrome P450 Mol Pharmacol, 2002; 61(2): 255-9. 

Beischlag, T. V. Wang, S. Rose, D. W. Torchia, J. Reisz-Porszasz, S. Muhammad, K. Nelson, W. E. Probst, M. R. Rosenfeld, M. G. Hankinson, O.   Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex Mol Cell Biol, 2002; 22(12): 4319-33. 

Anttila, S. Tuominen, P. Hirvonen, A. Nurminen, M. Karjalainen, A. Hankinson, O. Elovaara, E.   CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor Pharmacogenetics, 2001; 11(6): 501-9. 

Roth, M. D. Marques-Magallanes, J. A. Yuan, M. Sun, W. Tashkin, D. P. Hankinson, O.   Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol Am J Respir Cell Mol Biol, 2001; 24(3): 339-44. 

Lei, X. D. Chapman, B. Hankinson, O.   Loss of cyp1a1 messenger rna expression due to nonsense-mediated decayMol Pharmacol, 2001; 60(2): 388-93.

Beedanagari Sudheer R, Taylor Robert T, Hankinson Oliver   Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines. Toxicology letters, 2010; 194(1-2): 26-33. 

Wang Feng, Zhang Ruixue, Wu Xiaomeng, Hankinson Oliver   Roles of coactivators in hypoxic induction of the erythropoietin gene. PloS one, 2010; 5(4): e10002. 

Shi S, Yoon DY, Hodge-Bell K, Huerta-Yepez S, Hankinson O.   Aryl hydrocarbon nuclear translocator (hypoxia inducible factor 1beta) activity is required more during early than late tumor growth Mol Carcinog, 2010; 49(2): 157-65.

Hsu, E. L. Chen, N. Westbrook, A. Wang, F. Zhang, R. Taylor, R. T. Hankinson, O.   CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancersCancer Lett, 2008; 265(1): 113-23. 

Wang, F. Zhang, R. Xia, T. Hsu, E. Cai, Y. Gu, Z. Hankinson, O.   Inhibitory effects of nitric oxide on invasion of human cancer cells Cancer Lett, 2007; 257(2): 274-82.

Rivera, S. P. Wang, F. Saarikoski, S. T. Taylor, R. T. Chapman, B. Zhang, R. Hankinson, O.   A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia J Biol Chem, 2007; 282(15): 10881-93.

Saarikoski, S. T. Rivera, S. P. Hankinson, O. Husgafvel-Pursiainen, K.   CYP2S1: a short review Toxicol Appl Pharmacol, 2005; 207(2 Suppl): 62-9. 

Rivera, S. P. Choi, H. H. Chapman, B. Whitekus, M. J. Terao, M. Garattini, E. Hankinson, O.   Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes Toxicology, 2005; 207(3): 401-9. 

Hankinson, O.   Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor Arch Biochem Biophys, 2005; 433(2): 379-86. 

Beischlag, T. V. Taylor, R. T. Rose, D. W. Yoon, D. Chen, Y. Lee, W. H. Rosenfeld, M. G. Hankinson, O.   Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia J Biol Chem, 2004; 279(52): 

Fretland, A. J. Safe, S. Hankinson, O.   Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7 Chem Biol Interact, 2004; 150(2): 161-70. 

Wang, F. Zhang, R. Beischlag, T. V. Muchardt, C. Yaniv, M. Hankinson, O.   Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene J Biol Chem, 2004; 279(45): 46733-41. 

Wang, S. Ge, K. Roeder, R. G. Hankinson, O.   Role of mediator in transcriptional activation by the aryl hydrocarbon receptor J Biol Chem, 2004; 279(14): 13593-600. 

Anilkumar, G. Rajasekaran, S. A. Wang, S. Hankinson, O. Bander, N. H. Rajasekaran, A. K.   Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity Cancer Res, 2003; 63(10): 2645-8. 

Saarikoski, S. T. Rivera, S. P. Hankinson, O.   Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia FEBS Lett, 2002; 530(1-3): 186-90. 

Wang, S. Hankinson, O.   Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex J Biol Chem, 2002; 277(14): 11821-7. 

Yoon, D. Y. Buchler, P. Saarikoski, S. T. Hines, O. J. Reber, H. A. Hankinson, O.   Identification of genes differentially induced by hypoxia in pancreatic cancer cells Biochem Biophys Res Commun, 2001; 288(4): 882-6.

Heo, Y. Saxon, A. Hankinson, O.   Effect of diesel exhaust particles and their components on the allergen-specific IgE and IgG1 response in mice Toxicology, 2001; 159(3): 143-58. 

Education: 
PhD, Genetics, Cambridge University, England