Selected Publications
Hankinson, O. (1979). Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase. Proc. Nat. Acad. Sci. U.S.A. 76:373-376. PMID: 106390, PMCID: PMC382941 doi:10.1073/pnas.76.1.373.
Legraverend, C., Hannah, R., Eisen, H., Owens, O., Nebert, D., Hankinson, O. (1982). Regulatory gene product of the Ah locus: Characterization of receptor mutants among mouse hepatoma clones. J.Biol. Chem. 257:6402-6407. PMID: 6896205.
Hankinson, O. (1983). Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line, Hepa-1, and assignment of recessive mutants to three completmentation groups. Somat. Cell Genet. 9:497-514. doi: 10.1007/BF01543050. PMID: 6623311.
Van Gurp, J.R., Hankinson, O. (1983). Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase. Canc. Res. 43:6031-6038. PMID: 6640544.
Hankinson, O., Andersen RD, Birren BW, Sander F, Negishi M, Nebert DW. (1985) Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line. J Biol Chem 260(3):1790-5.PMID: 3968086.
Hoffman, E.C., Reyes, H., Chu, F., Sander, F., Conley, L.H., Brooks, B.A., Hankinson, O. (1991). Cloning of a factor required for activity of the Ah (dioxin) receptor. Science.252:954-958. doi: 10.1126/science. PMID: 1852076.
Reyes, H., Reisz-Porszasz, S., Hankinson, O., (1992). Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a component of the DNA building form of the Ah receptor. Science. 256:1193-1195. doi: 10.1126/science.256.5060.1193. PMID: 1317062.
Watson, A.J., Hankinson, O. (1992). Dioxin- and Ah receptor-dependent protein binding to xenobiotic responsive elements and G-rich DNA studied by in vivo footprinting. J. Biol. Chem. 266: 6874-6878. PMID: 1313025
Reisz-Porszasz, S., Probst, M.R. Fukunaga, B.N., Hankinson, O. (1994). Identification of Functional Domains of the Aryl Hydrocarbon Receptor Nuclear Translocator Protein (ARNT). Mol. Cell. Biol. 14:6075-6086. doi: 10.1128/mcb.14.9.6075-6086.1994. PMCID: PMC359134.
Hankinson, O. (1995). The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol.35:307-40. doi: 10.1146/annurev.pa.35.040195.001515. PMID: 7598497.
Fukunaga, B.N., Probst, M.R., Reisz-Porszasz, S., Hankinson, O. (1995). Identification of Functional Domains of the Aryl Hydrocarbon Receptor. J. Biol. Chem. 270:29270-29278. doi: 10.1074/jbc.270.49.29270. PMID: 7493958.
Fukunaga, B.N., Hankinson, O. (1996). Identification of a Novel Domain in The Aryl Hydrocarbon Receptor Required for DNA Binding. J. Biol. Chem. 271:3743-3749. doi: 10.1074/jbc.271.7.3743. PMID: 8631989.
Bacsi, S., Hankinson, O. (1996). Functional Characterization of DNA-Binding Domains of The Subunits of the Heterodimeric Aryl Hydrocarbon Receptor Complex Imputing Novel and Canonical Basic Helix-loop-Helix Protein-DNA Interactions. J. Biol. Chem. 271:8843-8850. doi: 10.1074/jbc.271.15.8843.PMID: 8621524.
Wood, S.M., Gleadle, J.M., Pugh, C.W., Hankinson, O., Ratcliffe, P.J. (1996). The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expresssion: Studies in ARNT Deficient Cells. J. Biol. Chem 271:15117-15123. doi: 10.1074/jbc.271.25.15117. PMID: 8662957.
Maxwell, P.H., Dachs, G.U., Gleadle, J.M., Nicholls, L.G., Harris, A.L., Stratford, I.J., Hankinson, O., Pugh, C.W., Ratcliffe, P.J. (1997). Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc.Natl. Acad. Sci. 94:8104-8109. doi: 10.1073/pnas.94.15.8104. PMID: 9223322 PMCID: PMC21564.
Kozak, K., Abbott, B., and Hankinson, O. (1997). ARNT-Deficient Mice and Placental Differentiation. Dev. Biol. 91:297-305. doi: 10.1006/dbio.1997.8758. PMID: 9398442.
Beischlag, T.V., Wang, S., Torchia, J., Reisz-Porszasz, S., Muhammad, K., Nelson, W.E., Probst, M.R., Rosenfeld, M.G., Hankinson, O. (2002). Recruitment of the NCoA/SRC-1/p160 Family of Transcriptional Co-activators by the Aryl Hydrocarbon Receptor/Aryl HydrocarbonReceptor Nuclear Translocator Complex. Mol. Cell. Biol. 22:4319-4333. doi: 10.1128/MCB.22.12.4319-4333.2002. PMID: 12024042.
Wang S., Hankinson, O. (2002). Functional involvement of the Brahma/SW12-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex. J Biol Chem.;277:11821-7. doi: 10.1074/jbc.M110122200. PMID: 11805098.
Wang, S., Ge, K., Roeder, R.G., Hankinson, O. (2004). Role of Mediator in Transcriptional Activation by the Aryl Hydrocarbon Receptor. J. Biol. Chem. 279:13593-13600. doi: 10.1074/jbc.M312274200. PMID: 14729673.
Beischlag, T.V., Taylor, R.T., Rose, D.W., Yoon, D., Chen, Y., Lee, W.H., Rosenfeld, M.G., Hankinson, O. (2004). Recruitment of Thyroid Hormone Receptor/Retinoblastoma Interacting Protein 230 (TRIP230) by Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) is Essential for the Transcriptional Response to both Dioxin and Hypoxia. J. Biol. Chem. 279:54620-8. doi: 10.1074/jbc.M410456200. PMID: 15485806.
Rivera, S.P., Wang F., Saarikoski, S.T., Taylor, R.T., Chapman, B., Zhang, R., and Hankinson, O. (2007). A Novel Promoter Element Containing Multiple Overlapping Xenobiotic and Hypoxia Response Elements Mediates Induction of Cytochrome P4502S1 by both Dioxin and Hypoxia. J. Biol. Chem. 282:10881-93. PMID: 17277313.
Huerta-Yepez, S., Baay-Guzman, G., Bebenek, I., Hernandez-Pando, R., Vega, M., Chi, L., Riedl, M., Diaz-Sanchez, D., Kleerup, E., Tashkin, D., Gonzalez, F., Bonavida, B., Zeidler, M., Hankinson, O. (2011). Hypoxia Inducible Factor Promotes Murine Allergic Airway Inflammation and is Increased in Asthma and Rhinitis. Allergy. 66:909-18. doi: 10.1111/j.1398-9995.2011.02594. PMID: 21517900. PMC3107385.
Bui, P., Solaimani, P., Wu, X., Hankinson, O. (2012). 2,3,7,8-Tetrachlorodibenzo-p-dioxin treatment alters eicosanoid levels in several organs of the mouse in an aryl hydrocarbon receptor-dependent fashion. Toxicol. Appl. Pharmacol. 259(2):143-51. PMID: 22230337. PMCID: PMC3288243.
Sundberg, C., Hankinson, O. (2019). A CRISPR/Cas9 whole-genome screen identifies genes required for Aryl Hydrocarbon Receptor-dependent induction of functional CYP1A1. Toxicol Sci. 170(2):310-319. doi: 10.1093/toxsci/kfz111.PMID: 31086989.
Huerta-Yepez, S., Tirado-Rodriguez, A., Montecillo-Aguado, MR, Yang, J., Hammock BD and Hankinson, O. (2020). Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression. Scientific Reports 10(1):7843. doi: 10.1038/s41598-020-64146-6. PMID: 32398692.