It’s been more than two years now since the coronavirus pandemic first arrived in the U.S., and it’s no surprise that “COVID fatigue” is setting in among many Americans who are ready to move on from the pandemic.

Roughly three in four adults across age, gender, race, political affiliation, and income groups said that “tired” and “frustrated” best describe how they feel about the current state of the pandemic, according to a late January survey conducted by the Kaiser Family Foundation.

In grappling with the COVID-19 pandemic, we’ve understandably had to place most of our focus on studying and combating the disease upending society. But beyond the direct health impacts of the virus, the pandemic has had reverberations that have thrown cities, workplaces, households and individual lives — into disarray.

It’s been more than three weeks since California eased its requirement that residents mask up in most indoor public areas, but not everyone has been quick to change their own daily habits.

Whether they’re still cautious about the state of the pandemic or simply acknowledge the continued protection masking provides, some doctors and public health experts are continuing to take precautions that go above and beyond the minimum mandates outlined at the state and local levels.

Here’s what they are saying:

Scarcely two months after the Omicron variant drove coronavirus case numbers to frightening heights in the United States, scientists and health officials are bracing for another swell in the pandemic and, with it, the first major test of the country’s strategy of living with the virus while limiting its impact.

The affluent city of Shanghai is going through a staggered lockdown this week as it battles its biggest surge of COVID cases in two years – more than 5,000 new case a day, a relatively huge amount for a city which had enjoyed near-zero cases for the last two years.

The stringent quarantine measures include home isolation for all residents and cancellation of all public transport while authorities test all 25 million residents – first in the city's eastern Pudong district, then in western Puxi district starting Friday.

Fox News (KTTV-TV) interviewed Dr. Anne Rimoin, UCLA Fielding School of Public Health professor of epidemiology and the Gordon-Levin Endowed Chair in Infectious Diseases and Public Health, about how best to prepare for a possible COVID-19 Omicron subvariant BA.2 or XE surge in southern California, following trends in Europe.

In its second year the UCLA Center for LGBTQ Advocacy, Research, and Health is expanding its work into myriad focuses of inquiry, from HIV and mental health to substance use issues. It is also conducting trainings about LGBTQ health for medical professionals and others interested in learning about the topic.

The center, also known as C-LARAH, has formed a partnership with the Los Angeles LGBT Center to work co-jointly on research projects. It is also being asked to provide expert testimony in court cases related to transgender health and aspects of LGBTQ health.

MSNBC interviewed Dr. Anne Rimoin, UCLA Fielding School of Public Health professor of epidemiology and the Gordon-Levin Endowed Chair in Infectious Diseases and Public Health, about the health risks of a federal court decision to void the U.S. national mask mandate covering airlines and other public transportation.

A new mask-optional phase of the pandemic is arriving, sparking concern from some experts that the shift is occurring too soon.

For months, local officials have been easing mask rules in public places, such as supermarkets and shopping malls. But a federal court ruling Monday striking down the federal mask-wearing order on public transportation systems accelerated the trend, with Uber, Lyft, many airlines and transit agencies making face coverings optional.

Lu Muying died on April 1 in a government quarantine facility in Shanghai, with her family on the phone as doctors tried to resuscitate her. She had tested positive for COVID-19 in late March and was moved there in line with government policy that all coronavirus cases be centrally isolated.