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Cases of COVID-19 are trending down nationally, and many states and cities are lifting mask and vaccine restrictions. But before you rush out to book your next vacation, experts say that the pandemic is not over yet. 

Nothing about the future course of the COVID-19 pandemic is certain. The coronavirus called SARS-CoV-2, which causes COVID-19 infections, is really difficult to predict. “The absolute truth of the matter is no one knows,” says Dr. Gregory Poland, head of Mayo Clinic's Vaccine Research Group.

The BBC interviewed Dr. Anne Rimoin, professor of epidemiology and the Gordon-Levin Endowed Chair in Infectious Diseases and Public Health at the UCLA Fielding School of Public Health, about the future of the pandemic response in the United States and globally.

Public health officials say California’s strict coronavirus policies in schools in recent months have resulted in relatively few pandemic-related campus closures.

Moreover, California’s rates of pediatric COVID-19 hospitalizations are the lowest among the nation’s six most populous states, health experts said.

So why have they decided to lift a statewide mask rule in K-12 schools after March 11, allowing schools to decide for themselves?

It’s been more than two years now since the coronavirus pandemic first arrived in the U.S., and it’s no surprise that “COVID fatigue” is setting in among many Americans who are ready to move on from the pandemic.

Roughly three in four adults across age, gender, race, political affiliation, and income groups said that “tired” and “frustrated” best describe how they feel about the current state of the pandemic, according to a late January survey conducted by the Kaiser Family Foundation.

In grappling with the COVID-19 pandemic, we’ve understandably had to place most of our focus on studying and combating the disease upending society. But beyond the direct health impacts of the virus, the pandemic has had reverberations that have thrown cities, workplaces, households and individual lives — into disarray.

It’s been more than three weeks since California eased its requirement that residents mask up in most indoor public areas, but not everyone has been quick to change their own daily habits.

Whether they’re still cautious about the state of the pandemic or simply acknowledge the continued protection masking provides, some doctors and public health experts are continuing to take precautions that go above and beyond the minimum mandates outlined at the state and local levels.

Here’s what they are saying:

Scarcely two months after the Omicron variant drove coronavirus case numbers to frightening heights in the United States, scientists and health officials are bracing for another swell in the pandemic and, with it, the first major test of the country’s strategy of living with the virus while limiting its impact.

The affluent city of Shanghai is going through a staggered lockdown this week as it battles its biggest surge of COVID cases in two years – more than 5,000 new case a day, a relatively huge amount for a city which had enjoyed near-zero cases for the last two years.

The stringent quarantine measures include home isolation for all residents and cancellation of all public transport while authorities test all 25 million residents – first in the city's eastern Pudong district, then in western Puxi district starting Friday.

Fox News (KTTV-TV) interviewed Dr. Anne Rimoin, UCLA Fielding School of Public Health professor of epidemiology and the Gordon-Levin Endowed Chair in Infectious Diseases and Public Health, about how best to prepare for a possible COVID-19 Omicron subvariant BA.2 or XE surge in southern California, following trends in Europe.