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John Froines

Professor Emeritus
Contact Information

UCLA Fielding School of Public Health
650 Charles E. Young Drive South 21-293C CHS
Los Angeles, CA 90095

Areas of Interest: 

Occupational Health

Professor Froines joined the faculty of the School of Public Health in 1981. He received a B.S. in chemistry from UC Berkeley (1963), M.S. in chemistry (1964) and Ph.D. in physical-organic chemistry (1967) from Yale University. He conducted postdoctoral research at the Royal Institution of Great Britain under Nobel Laureate, Sir George Porter from 1966-68. Before coming to the UCLA School of Public Health, Dr. Froines was Assistant Professor of Chemistry at the University of Oregon and later served as Director of Toxic Substances at the Occupational Safety and Health Administration and Deputy Director of the National Institute for Occupational Safety and Health. Dr. Froines served as the Director of the Center for Occupational and Environmental Health for 25 years and is currently the Director of the Southern California Particle Center and Supersite. He is Associate Director of the Southern California Environmental Health Sciences Center and the Director of the UCLA Fogarty Program in Occupational and Environmental Health. He is Director of the Sustainable Technology and Policy Program. He serves on three advisory committees of the South Coast Air Quality Management District. Dr. Froines' area of expertise is toxicology and exposure assessment. His research interests are in the qualitative and quantitative characterization of risk factors in environmental and occupational health. 

Dr. Froines chairs the State of California's Scientific Review Panel; the central review panel at the State level for identifying toxic air contaminants. 

PhD, Physical-Organic Chemistry, Yale University
MS, Physical-Organic Chemistry, Yale University
BS, Chemistry, University of California, Berkeley
Selected Publications: 

Breysse, P.N., R.J. Delfino, F. Dominici, A.C P. Elder, M.W. Frampton, J.R. Froines, A.S. Geyh, J.J. Godleski, D.R. Gold, P.K. Hopke, P. Koutrakis, N. Li, G. Oberdörster, K.E. Pinkerton, J.M. Samet, M.J. Utell, A.S. Wexler. U.S. EPA Particulate Matter Research Centers: Summary of Research Results for 2005–2011. Air Quality, Atmosphere and Health ; (in press): .

Zhu Y, Fanning E, Yu RC, Zhang Q, Froines JR Aircraft emissions and local air quality impacts from takeoff activities at a large International Airport. Atmospheric Environment 2011; ISSN 1352-2310, 10.1016/j.atmosenv.2011.08.062( .

Iwamoto N, Nishiyama A, Eiguren-Fernandez A, Hinds W, Kumagai Y, Froines J, Cho A and Shinyashiki M. Biochemical and cellular effects of electrophiles present in ambient air samples. Atmospheric Environment, 2010; 44: 1483-1489.

Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y. Effects of a single intratracheal administration of phenanthraquinone on murine lung. Journal of applied toxicology. 2005; 25(1): 47-51.

Cho, AK, Di, Stefano E, You Y, Rodriguez CE, Schmitz DA, Kumagai Y, Miguel AH, Eiguren-Fernandez A, Kobayashi T, Avol E, Froines JR. Determination of Four Quinones in Diesel Exhaust Particles, SRM 1649a and Atmospheric PM2.5. Aerosol Science and Technology 2003; .

Eiguren-Fernandez Arantzazu, Shinyashiki Masaru, Schmitz Debra A, DiStefano Emma, Hinds William, Kumagai Yoshito, Cho Arthur K, Froines John R Redox and electrophilic properties of vapor- and particle-phase components of ambient aerosols.. Environmental research. 2010; 110(3): 207-12.

DiStefano Emma, Eiguren-Fernandez Arantzazu, Delfino Ralph J, Sioutas Constantinos, Froines John R, Cho Arthur K Determination of metal-based hydroxyl radical generating capacity of ambient and diesel exhaust particles.. Inhalation toxicology. 2009; 21(9): 731-8.

Shinyashiki Masaru, Eiguren-Fernandez Arantza, Schmitz Debra A, Di Stefano Emma, Li Ning, Linak William P, Cho Seung-Hyun, Froines John R, Cho Arthur K Electrophilic and redox properties of diesel exhaust particles.. Environmental research. 2009; 109(3): 239-44.

Fanning Elinor W, Froines John R, Utell Mark J, Lippmann Morton, Oberdörster Gunter, Frampton Mark, Godleski John, Larson Tim V Particulate matter (PM) research centers (1999-2005) and the role of interdisciplinary center-based research.. Environmental health perspectives. 2009; 117(2): 167-74.

Taguchi Keiko, Shimada Megumi, Fujii Sayako, Sumi Daigo, Pan Xiaoqing, Yamano Shigeru, Nishiyama Takahito, Hiratsuka Akira, Yamamoto Masayuki, Cho Arthur K, Froines John R, Kumagai Yoshito Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells.. Free radical biology & medicine. 2008; 44(8): 1645-55.

Ayres Jon G, Borm Paul, Cassee Flemming R, Castranova Vincent, Donaldson Ken, Ghio Andy, Harrison Roy M, Hider Robert, Kelly Frank, Kooter Ingeborg M, Marano Francelyne, Maynard Robert L, Mudway Ian, Nel Andre, Sioutas Constantinos, Smith Steve, Baeza-Squiban Armelle, Cho Art, Duggan Sean, Froines John Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential--a workshop report and consensus statement.. Inhalation toxicology. 2008; 20(1): 75-99.

Solomon Paul A, Hopke Philip K, Froines John, Scheffe Richard Key scientific findings and policy- and health-relevant insights from the U.S. Environmental Protection Agency's Particulate Matter Supersites Program and related studies: an integration and synthesis of results.. Journal of the Air & Waste Management Association (1995). 2008; 58(13 Suppl): S3-92.

Abdo Kamal M, Camargo Carlos A, Davis Devra, Egilman David, Epstein Samuel S, Froines John, Hattis Dale, Hooper Kim, Huff James, Infante Peter F, Jacobson Michael F, Teitelbaum Daniel Thau, Tickner Joel A Letter to U.S. FDA commissioner. Questions about the safety of the artificial sweetener aspartame.. International journal of occupational and environmental health. 2008; 13(4): 449-50.

Iwamoto Noriko, Sumi Daigo, Ishii Takeshi, Uchida Koji, Cho Arthur K, Froines John R, Kumagai Yoshito Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor.. The Journal of biological chemistry. 2007; 282(46): 33396-404.

Taguchi Keiko, Fujii Sayako, Yamano Shigeru, Cho Arthur K, Kamisuki Shinji, Nakai Yumi, Sugawara Fumio, Froines John R, Kumagai Yoshito An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress.. Free radical biology & medicine. 2007; 43(5): 789-99.

Kleinman Michael T, Sioutas Constantinos, Froines John R, Fanning Elinor, Hamade Ali, Mendez Loyda, Meacher Dianne, Oldham Michael Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice.. Inhalation toxicology. 2007; 19 Suppl 1(5): 117-26.

Ntziachristos Leonidas, Froines John R, Cho Arthur K, Sioutas Constantinos Relationship between redox activity and chemical speciation of size-fractionated particulate matter.. Particle and fibre toxicology. 2007; 4(5): 5.

Kikuno Shota, Taguchi Keiko, Iwamoto Noriko, Yamano Shigeru, Cho Arthur K, Froines John R, Kumagai Yoshito 1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea.. Toxicology and applied pharmacology. 2006; 210(1-2): 47-54.

Sabty-Daily RA, Harris PA, Hinds WC, Froines JR. Size distribution and speciation of chromium in paint spray aerosol at an aerospace facility. The Annals of occupational hygiene. 2005; 49(1): 47-59.

Sabty-Daily RA, Hinds WC, Froines JR. Size distribution of chromate paint aerosol generated in a bench-scale spray booth. The Annals of occupational hygiene. 2005; 49(1): 33-45.

Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environmental health perspectives. 2003; 111(4): 455-60.

Okoji RS, Yu RC, Maronpot RR, Froines JR. Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice. Carcinogenesis. 2002; 23(5): 777-85.

Li N, Kim S, Wang M, Froines J, Sioutas C, Nel A. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhalation toxicology. 2002; 14(5): 459-86.

Yu RC, Hattis D, Landaw EM, Froines JR. Toxicokinetic interaction of 2,5-hexanedione and methyl ethyl ketone. Archives of toxicology. 2002; 75(11-12): 643-52.